Inability of dimethyl sulfoxide and 5-fluorouracil to open the blood-brain barrier.

@article{Neuwelt1983InabilityOD,
  title={Inability of dimethyl sulfoxide and 5-fluorouracil to open the blood-brain barrier.},
  author={Edward A Neuwelt and Peter A. Barnett and John A. Barranger and Crystal McCormick and Mark Pagel and Eugene P. Frenkel},
  journal={Neurosurgery},
  year={1983},
  volume={12 1},
  pages={29-34}
}
The inability of most chemotherapeutic agents to adequately penetrate the blood-brain barrier (BBB), in either normal brain or tumor-infiltrated brain, is a major factor limiting the use of chemotherapy in central nervous system malignancy. This barrier, however, can be opened in a reversible manner by the intra-arterial administration of hyperosmotic agents such as mannitol. It has been suggested that the intravenous administration of dimethyl sulfoxide (DMSO) or 5-fluorouracil (5-FU) can… CONTINUE READING