In vivo zippering of inner and outer mitochondrial membranes by a stable translocation intermediate.

@article{Schlke1997InVZ,
  title={In vivo zippering of inner and outer mitochondrial membranes by a stable translocation intermediate.},
  author={N Sch{\"u}lke and Naresh Babu Venkata Sepuri and Debkumar Pain},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 14},
  pages={7314-9}
}
It was previously assumed that the import of cytoplasmically synthesized precursor proteins into mitochondria occurs through a single structure spanning both outer and inner membranes at contact sites. Based on recent findings, however, the two membranes appear to contain independent translocation elements that reversibly cooperate during protein import. This feature makes it difficult to generate a means of isolating a fully integrated and functional translocation complex. To study these… CONTINUE READING

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