In vivo zebrafish assays for toxicity testing.

@article{Parng2005InVZ,
  title={In vivo zebrafish assays for toxicity testing.},
  author={Chuenlei Parng},
  journal={Current opinion in drug discovery & development},
  year={2005},
  volume={8 1},
  pages={
          100-6
        }
}
  • Chuenlei Parng
  • Published in Current opinion in drug discovery & development 2005
Toxicity, due to complications of in vivo adsorption, distribution, metabolism and excretion (ADME), is a major cause of failure during drug development; many drugs shown to be safe in cell culture prove toxic in animal studies. Effective in vivo toxicity screening early in the development process can reduce the number of compounds that progress to laborious and costly late-stage animal testing. The transparent zebrafish provides accessibility to internal organs, tissues and even cells, and has… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

Similar Papers

Loading similar papers…