In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.

@article{Cao2006InVV,
  title={In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.},
  author={Feng Cao and Shuan Lin and Xiaoyan Xie and Pritha Ray and Manishkumar Patel and Xianzhong Zhang and Micha Drukker and Scott J. Dylla and Andrew J Connolly and Xiaoyuan Chen and Irving L Weissman and Sanjiv Sam Gambhir and Joseph C Wu},
  journal={Circulation},
  year={2006},
  volume={113 7},
  pages={1005-14}
}
BACKGROUND Recent studies have shown that stem cell therapy can promote tissue regeneration; however, monitoring stem cells in vivo remains problematic owing to limitations of conventional histological assays and imaging modalities. METHODS AND RESULTS Murine embryonic stem (ES) cells were stably transduced with a lentiviral vector carrying a novel triple-fusion (TF) reporter gene that consists of firefly luciferase, monomeric red fluorescence protein, and truncated thymidine kinase (fluc… CONTINUE READING

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