In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent.

@article{Jack2004InVV,
  title={In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent.},
  author={Clifford R. Jack and M. Garwood and T. M. Wengenack and Bret J. Borowski and G. L. Curran and Joseph Lin and Gregor Adriany and Olli H. J. Gr{\"o}hn and Roger C. Grimm and J. F. Poduslo},
  journal={Magnetic resonance in medicine},
  year={2004},
  volume={52 6},
  pages={1263-71}
}
One of the cardinal pathologic features of Alzheimer's disease (AD) is the formation of senile, or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop "human-like" plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been accomplished with other modalities, but only MRI has sufficient spatial and contrast resolution to… CONTINUE READING
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