In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.

@article{Shah2001InVV,
  title={In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.},
  author={A S Shah and D C White and S Emani and Alan P. Kypson and Richard Lilly and K Wilson and Donald D. Glower and R J Lefkowitz and W J Koch},
  journal={Circulation},
  year={2001},
  volume={103 9},
  pages={1311-6}
}
  • A S Shah, D C White, +6 authors W J Koch
  • Published 2001 in Circulation
BACKGROUND Genetic manipulation to reverse molecular abnormalities associated with dysfunctional myocardium may provide novel treatment. This study aimed to determine the feasibility and functional consequences of in vivo beta-adrenergic receptor kinase (betaARK1) inhibition in a model of chronic left ventricular (LV) dysfunction after myocardial infarction (MI). METHODS AND RESULTS Rabbits underwent ligation of the left circumflex (LCx) marginal artery and implantation of sonomicrometric… CONTINUE READING