In vivo validation of a computational bone adaptation model using open-loop control and time-lapsed micro-computed tomography.

@article{Schulte2011InVV,
  title={In vivo validation of a computational bone adaptation model using open-loop control and time-lapsed micro-computed tomography.},
  author={Friederike A. Schulte and Floor M. Lambers and Duncan James Webster and Gisela Kuhn and Ralph M{\"u}ller},
  journal={Bone},
  year={2011},
  volume={49 6},
  pages={1166-72}
}
Cyclic mechanical loading augments trabecular bone mass, mainly by increasing trabecular thickness. For this reason, we hypothesized that an in silico thickening algorithm using open-loop control would be sufficient to reliably predict the response of trabecular bone to cyclic mechanical loading. This would also mean that trabecular bone adaptation could be modeled as a system responding to an input signal at the onset of the process in a predefined manner, without feedback from the outputs… CONTINUE READING