In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes.

@article{Kozai2012InVT,
  title={In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes.},
  author={Takashi D. Y. Kozai and Alberto Vazquez and Cassandra Lynn Weaver and Seong-Gi Kim and Xinyan Tracy Cui},
  journal={Journal of neural engineering},
  year={2012},
  volume={9 6},
  pages={066001}
}
OBJECTIVE Penetrating cortical neural probe technologies allow investigators to record electrical signals in the brain. Implantation of probes results in acute tissue damage, and microglia density increases around implanted devices over weeks. However, the mechanisms underlying this encapsulation are not well understood in the acute temporal domain. The objective here was to evaluate dynamic microglial response to implanted probes using two-photon microscopy. APPROACH Using two-photon in vivo… CONTINUE READING
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