In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags

@article{Qian2008InVT,
  title={In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags},
  author={Ximei Qian and X Peng and Dominic O Ansari and Qiqin Yin-Goen and Georgia Zhuo Chen and Dong M Shin and Lily C Yang and Andrew N. Young and May D. Wang and Shuming Nie},
  journal={Nature Biotechnology},
  year={2008},
  volume={26},
  pages={83-90}
}
We describe biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold nanoparticles and surface-enhanced Raman scattering (SERS). Colloidal gold has been safely used to treat rheumatoid arthritis for 50 years, and has recently been found to amplify the efficiency of Raman scattering by 14–15 orders of magnitude. Here we show that large optical enhancements can be achieved under in vivo conditions for tumor detection in live animals. An important… CONTINUE READING
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