In vivo treatment with monoclonal antibody 3.2.3 selectively eliminates natural killer cells in rats

@article{Brink1990InVT,
  title={In vivo treatment with monoclonal antibody 3.2.3 selectively eliminates natural killer cells in rats},
  author={Marcel R M van den Brink and Louise E Hunt and John C. Hiserodt},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={171},
  pages={197 - 210}
}
We recently described a mAb 3.2.3 (IgG1), that recognizes a 60-kD dimeric molecule expressed exclusively on fresh and rIL-2-activated NK cells and polymorphonuclear cells. mAb 3.2.3 enhances cytolytic activity of NK cells against selected FcR+ tumor target cells by reverse antibody-dependent cellular cytotoxicity (ADCC), indicating that it recognizes an important triggering site on NK cells. The in vivo treatment of F344 rats with mAb 3.2.3 intraperitoneally completely and selectively… CONTINUE READING
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