In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro.

@article{Leavey1998InVT,
  title={In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro.},
  author={Patrick S Leavey and Karen S. Sellins and Gary B. Thurman and David J. Elzi and Andrew A Hiester and Christopher C. Silliman and Gary O. Zerbe and Justin J. Cohen and Daniel R. Ambruso},
  journal={Blood},
  year={1998},
  volume={92 11},
  pages={4366-74}
}
We have studied the effects of granulocyte colony-stimulating factor (G-CSF) administration to normal individuals on a variety of functional and biochemical neutrophil characteristics that relate to host defense. G-CSF adversely affected neutrophil (polymorphonuclear leukocyte [PMN]) chemotaxis. While this could be partially explained by reduced assembly of neutrophil F-actin, we also recognized an elevated cytosolic calcium mobilization and a normal upregulation of neutrophil CD11b. G-CSF… CONTINUE READING