In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+

@article{Obata2005InVT,
  title={In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+},
  author={T. Obata and Chuang Chin Chiueh},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={89},
  pages={139-145}
}
  • T. Obata, Chuang Chin Chiueh
  • Published in
    Journal of Neural…
    2005
  • Medicine, Chemistry
  • Increased formation of hydroxyl free radicals (·OH) reflected by ·OH adduct of salicylate in brain dialysate was demonstrated during the sustained (more than 2 hours) dopamine overflow elicited by 75 nmol of 1-methyl-4-phenyldihydropyridine (MPDP+) and 1-methyl-4-phenylpyridinium (MPP+) in the rat striatum. Owing to its weak dopamine releasing action, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) did not significantly increase the ·OH formation. This data suggests that sustained elevation… CONTINUE READING

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