In vivo toxicity of a synthetic dodecapeptide from A gliadin in patients with coeliac disease.

@article{Mantzaris1991InVT,
  title={In vivo toxicity of a synthetic dodecapeptide from A gliadin in patients with coeliac disease.},
  author={Gerassimos Mantzaris and Derek P. Jewell},
  journal={Scandinavian journal of gastroenterology},
  year={1991},
  volume={26 4},
  pages={392-8}
}
A single dose of a synthetic peptide of A gliadin (residues 206-217) sharing homology with the E1b protein of adenovirus 12 was instilled intraduodenally in two treated coeliac patients. Biopsy specimens were taken before and repeatedly up to 24 h after the instillation by means of a Quinton hydraulic multiple biopsy instrument and processed for histology, morphometry (intraepithelial lymphocyte counts, crypt-to-villus ratio), immunocytochemistry, electron microscopy, and disaccharidase assays… CONTINUE READING

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