In vivo tissue disposition of 3'-azido-3'-deoxythymidine and its anabolites in control and retrovirus-infected mice.

@article{Chow1997InVT,
  title={In vivo tissue disposition of 3'-azido-3'-deoxythymidine and its anabolites in control and retrovirus-infected mice.},
  author={H-H. Sherry Chow and Ping Li and Gary Brookshier and Yahong Tang},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1997},
  volume={25 4},
  pages={412-22}
}
At present, 3'-azido-3'-deoxythymidine (AZT; zidovudine) remains the drug of choice for initiating AIDS therapy. This drug in itself is inactive; it needs to be converted intracellularly by a series of cellular kinases to AZT 5'-triphosphate (AZT-TP) to exert antiviral activity. The purpose of this study was to examine the in vivo disposition of the phosphorylated AZT anabolites in different target tissues and to investigate the effects of chronic retrovirus infection on the tissue disposition… CONTINUE READING
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Showing 1-10 of 35 references

toxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine model of AIDS

  • K. C. Chadha I. Stadler, S. Nakeeb, +5 authors S. K. Satchidanand
  • J . Pharmacol . Exp . Ther .
  • 1994

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