In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging.

@article{Xue1999InVT,
  title={In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging.},
  author={Rong Xue and P C M van Zijl and Barbara J. Crain and Meiyappan Solaiyappan and Susumu Mori},
  journal={Magnetic resonance in medicine},
  year={1999},
  volume={42 6},
  pages={1123-7}
}
The in situ assessment of axonal projections of the brain has been severely limited by the lack of noninvasive techniques to study this type of anatomy. We show here that in vivo three-dimensional (3D) reconstruction of axonal projections can be achieved using a rapid 3D high-resolution diffusion-weighted imaging technique combined with a recently designed fiber reconstruction algorithm. As a first example, neuronal pathways in the rat brain were probed. Eight well-known fiber projections; genu… CONTINUE READING
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