In vivo therapy of local tumor progression by targeting vascular endothelium with EMAP-II.

@article{Schwarz2004InVT,
  title={In vivo therapy of local tumor progression by targeting vascular endothelium with EMAP-II.},
  author={Roderich E Schwarz and Margaret A Schwarz},
  journal={The Journal of surgical research},
  year={2004},
  volume={120 1},
  pages={
          64-72
        }
}
BACKGROUND Continued growth of solid tumors beyond a critical diameter is thought to require active angiogenic mechanisms, the inhibition of which carries therapeutic potential. We tested this strategy in an in vivo model of local tumor progression utilizing an agent with previously identified direct antiendothelial properties. MATERIALS AND METHODS Nonmetastatic C(6) glioma cells (10(6) per animal) were injected subcutaneously into the flank of nude mice with 6 to 8 animals per treatment… CONTINUE READING
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