In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques.

@article{Poduslo2007InVT,
  title={In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques.},
  author={J. F. Poduslo and Muthu Ramakrishnan and S. S. Holasek and Marina Ram{\'i}rez-Alvarado and Karunya K. Kandimalla and E. J. Gilles and Geoffry L. Curran and T. M. Wengenack},
  journal={Journal of neurochemistry},
  year={2007},
  volume={102 2},
  pages={
          420-33
        }
}
Targeting therapeutic or diagnostic proteins to the nervous system is limited by the presence of the blood-brain barrier. We report that a F(ab')(2) fragment of a monoclonal antibody against fibrillar human Abeta42 that is polyamine (p)-modified has increased permeability at the blood-brain barrier, comparable binding to the antigen, and comparable in vitro binding to amyloid plaques in Alzheimer's disease (AD) transgenic mouse brain sections. Intravenous injection of the pF(ab')(2)4.1 in the… CONTINUE READING
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