In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium

@article{Kim2005InVT,
  title={In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium},
  author={Sang Wook Kim and Seung Dae Yang and Byung-Jae Ahn and Jeong Hoon Park and Dong Soo Lee and Guido Gessner and Stefan H. Heinemann and Wilhelm Herdering and Kook Hyun Yu},
  journal={Experimental & Molecular Medicine},
  year={2005},
  volume={37},
  pages={269-275}
}
The antiarrhythmic clofilium is an efficient blocker of hERG1 potassium channels that are strongly expressed in the heart. Therefore, derivatives of clofilium that emit positrons might be useful tools for monitoring hERG1 channels in vivo. Fluoroclofilium (F-clofilium) was synthesized and its channel-blocking properties were determined for hERG1 and hEAG1 channels expressed in HEK 293 cells and in Xenopus oocytes. When applied extracellularly in the whole-cell patch-clamp configuration, F… CONTINUE READING

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