In vivo targeted gene delivery to peripheral neurons mediated by neurotropic poly(ethylene imine)-based nanoparticles

@inproceedings{Lopes2016InVT,
  title={In vivo targeted gene delivery to peripheral neurons mediated by neurotropic poly(ethylene imine)-based nanoparticles},
  author={C F Daniella Lopes and Hugo Santos Oliveira and In{\^e}s Estev{\~a}o and Liliana R Pires and Ana Paula P{\^e}go},
  booktitle={International journal of nanomedicine},
  year={2016}
}
A major challenge in neuronal gene therapy is to achieve safe, efficient, and minimally invasive transgene delivery to neurons. In this study, we report the use of a nonviral neurotropic poly(ethylene imine)-based nanoparticle that is capable of mediating neuron-specific transfection upon a subcutaneous injection. Nanoparticles were targeted to peripheral neurons by using the nontoxic carboxylic fragment of tetanus toxin (HC), which, besides being neurotropic, is capable of being retrogradely… CONTINUE READING
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