In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation.

@article{Shimada2008InVT,
  title={In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation.},
  author={Masako Shimada and Peter A. Greer and Andrew P. McMahon and Mary L Bouxsein and Ernestina Schipani},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 30},
  pages={21002-10}
}
Calpains are intracellular cysteine proteases, which include widely expressed mu- and m-calpains (1). Both mu-calpains and m-calpains are heterodimers consisting of a large catalytic subunit and a small regulatory subunit. The calpain small subunit encoded by the gene Capn4 directly binds to the intracellular C-terminal tail (C-tail) of the receptor for parathyroid hormone and parathyroid hormone-related peptide and modulates its cellular functions in osteoblasts in vitro (2). To investigate a… CONTINUE READING

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