In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models.

@article{Lee2005InVT,
  title={In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models.},
  author={Sang Hoon Lee and Daniel E Lopes de Menezes and Jayesh Vora and Alexandra Harris and Helen Ye and Lara Nordahl and Evelyn N. Garrett and Emil Samara and Sharon Lea Aukerman and Arnold B. Gelb and Carla Heise},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 10},
  pages={3633-41}
}
PURPOSE To evaluate the therapeutic and biological effects of CHIR-258, an orally bioavailable, potent inhibitor of class III-V receptor tyrosine kinases, in colon cancer models. EXPERIMENTAL DESIGN The pharmacologic activity of CHIR-258 was characterized by monitoring target modulation as well as by evaluating the antitumor and antiangiogenic effects in human colon xenograft models. RESULTS CHIR-258 inhibits vascular endothelial growth factor receptor 1/2, fibroblast growth factor receptor… CONTINUE READING
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