In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid

@article{Stoenica2006InVS,
  title={In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid},
  author={Luminita Stoenica and Oleg N. Senkov and Rita Gerardy-Schahn and Birgit Weinhold and Melitta Schachner and Alexander E Dityatev},
  journal={European Journal of Neuroscience},
  year={2006},
  volume={23}
}
The neural cell adhesion molecule NCAM and its associated polysialic acid (PSA) play important roles in synaptic plasticity in the CA1 and/or CA3 regions of the hippocampus in vitro. Here, we address the question of whether NCAM and PSA are involved in regulation of synaptic transmission and plasticity also in vivo at synapses formed by entorhinal cortex axons in the dentate gyrus of mice anaesthetized with urethane. We show that basal synaptic transmission, measured as the slope of field… 
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TLDR
Findings implicate carbohydrates carried by adhesion molecules in modulating NMDA receptor signaling in the brain and demonstrate reversibility of cognitive deficits associated with ablation of a schizophrenia-related adhesion molecule.
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TLDR
Results show for the first time that enhancing NCAM functions by mimicking its heterophilic interaction with FGFR facilitates hippocampal synaptic plasticity in the awake, freely moving animal.
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TLDR
Analysis of CHL1-deficient mice illustrates that at intermediate stages of development a deficit in a cell adhesion molecule is compensated but appears as impaired LTP during early and late postnatal development.
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TLDR
Data support the view that polysialylated NCAM is involved in both formation and late consolidation of contextual memory and the impact of PSA-NCAM in synaptic plasticity and learning is not mediated by modulation of NCAM–NCAM homophilic interactions.
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TLDR
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TLDR
In mature brains, NCAM is important for induction of NMDA receptor-dependent long-term potentiation and depression in the CA1 area of the hippocampus, LTP-associated increase in the number of perforated synapses, NMDA receptors-independent mossy fiber LTP, several forms of learning and memory and morphological plasticity in the hypothalamo-neurohypophysial system.
N-methyl-D-aspartate receptor independent changes in expression of polysialic acid-neural cell adhesion molecule despite blockade of homosynaptic long-term potentiation and heterosynaptic long-term depression in the awake freely behaving rat dentate gyrus.
TLDR
These findings suggest that strong activation of the granule cells up-regulates PSA-NCAM synthesis which then incorporates into activated synapses, representing NMDA-independent plastic processes that act synergistically on LTP/LTD mechanisms without participating in their expression.
Dendritic spine and synapse morphological alterations induced by a neural cell adhesion molecule mimetic.
TLDR
Quantitative electron microscopy and 3-dimensional reconstruction of ultrathin serial sections has been used to examine the morphology of synapses and dendritic spines in the hippocampus of rats treated with a neural cell adhesion molecule-derived fibroblast growth factor receptor agonist, FGL-peptide (an NCAM mimetic).
Neural cell adhesion molecule ablation in mice causes hippocampal dysplasia and loss of septal cholinergic neurons
TLDR
It is indicated that NCAM ablation causes structural abnormalities in the hippocampus and the forebrain cholinergic system in adult mice, which may contribute to impaired cognition in NCAM−/− mice.
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