In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI

@article{Lamfers2001InVS,
  title={In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI},
  author={Martine L. M. Lamfers and J H P Lardenoye and Margreet R. de Vries and Marjanka C Aalders and Marten A. Engelse and J. Grimbergen and Victor W. M. van Hinsbergh and P H A Quax},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={534-541}
}
Injury-induced neointimal development results from migration and proliferation of vascular smooth muscle cells (SMC). Cell migration requires controlled proteolytic degradation of extracellular matrix surrounding the cell. Plasmin is a major contributor to this process by degrading various matrix proteins directly, or indirectly by activating matrix metalloproteinases. This makes it an attractive target for inhibition by gene transfer. An adenoviral vector, Ad.ATF.BPTI, was constructed encoding… CONTINUE READING