• DOI:10.1096/fj.201600604r
Corpus ID: 205375458

In vivo studies validating multitargeting of prostanoid receptors for achieving superior anti‐inflammatory effects

@article{Woodward2017InVS,
  title={In vivo studies validating multitargeting of prostanoid receptors for achieving superior anti‐inflammatory effects},
  author={D. Woodward and J. Wang and Ming Ni and Alex Bauer and J. Martos and R. W. Carling and N. Poloso},
  journal={The FASEB Journal},
  year={2017},
  volume={31},
  pages={368 - 375}
}

D. Woodward, J. Wang, +4 authors N. Poloso

Published 2017

Biology, Medicine

The FASEB Journal

The purpose of these studies was to test the hypothesis that a selected polypharmacological approach for treating the prostanoid‐mediated component of inflammatory diseases would produce a therapeutic effect superior to global inhibition of prostaglandin (PG) biosynthesis by aspirin‐like drugs. The compound studied was AGN 211377, which had been previously shown to produce a superior effect on cytokine release from human macrophages compared with cyclooxygenase (COX) inhibitors. AGN 211377… CONTINUE READING

View on Wiley

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed