In vivo studies support the role of trafficking and cytoskeletal-binding motifs in the interaction of MESA with the membrane skeleton of Plasmodium falciparum-infected red blood cells.

@article{Black2008InVS,
  title={In vivo studies support the role of trafficking and cytoskeletal-binding motifs in the interaction of MESA with the membrane skeleton of Plasmodium falciparum-infected red blood cells.},
  author={Casilda G. Black and Nicholas I Proellocks and Lev M. Kats and Brian M. Cooke and Narla Mohandas and Ross L Coppel},
  journal={Molecular and biochemical parasitology},
  year={2008},
  volume={160 2},
  pages={143-7}
}
In red blood cells (RBCs) infected with the malaria parasite Plasmodium falciparum, a 19-residue region of the mature parasite-infected erythrocyte surface antigen (MESA) associates with RBC cytoskeleton protein 4.1R; an interaction essential for parasite survival. This region in MESA is adjacent to a host targeting motif found in other malaria parasite proteins exported to the membrane skeleton. To demonstrate function of these motifs in vivo, regions of MESA fused to a reporter were expressed… CONTINUE READING

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