In vivo studies on the dynamics of histone-DNA interaction: evidence for nucleosome dissolution during replication and transcription and a low level of dissolution independent of both.

@article{Jackson1990InVS,
  title={In vivo studies on the dynamics of histone-DNA interaction: evidence for nucleosome dissolution during replication and transcription and a low level of dissolution independent of both.},
  author={Vaughn E Jackson},
  journal={Biochemistry},
  year={1990},
  volume={29 3},
  pages={
          719-31
        }
}
Histones have been both radiolabeled and density-labeled with amino acids in vivo to determine the dynamics of histone-DNA and histone-histone interactions at the replication fork and on active genes. Proteins were uniformly labeled and subsequently chased for three cell generations. During the chase period, H3,H4 tetramers dissociated from the H2A,H2B dimers to re-form nucleosomes with the corresponding nondense histones synthesized during the chase period. These data suggest that the… CONTINUE READING
Highly Cited
This paper has 81 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 65 citations

81 Citations

0510'90'96'03'10'17
Citations per Year
Semantic Scholar estimates that this publication has 81 citations based on the available data.

See our FAQ for additional information.