In vivo studies of the role of factor VII in hemostasis.

@article{Giles1985InVS,
  title={In vivo studies of the role of factor VII in hemostasis.},
  author={Alan R. Giles and Shawn Tinlin and L Brosseau and Hendrik Hoogendoorn},
  journal={Blood},
  year={1985},
  volume={65 5},
  pages={
          1197-200
        }
}
The effect of both congenital and acquired factor VII deficiency on the cuticle bleeding time (CBT) was evaluated in dogs. The CBT has been previously documented to be a sensitive indicator of factor VIII:C deficiency in hemophilic dogs. Serial CBT determinations were made on normal dogs treated with high-dose warfarin. At 48 hours post-treatment, the CBT was normal, although the factor VII level was less than 1%, whereas the levels of factors II, IX, and X were 44%, 25%, and 17%, respectively… CONTINUE READING

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