In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent.

@article{Xu1996InVS,
  title={In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent.},
  author={Cai-min Xu and John E. Johnson and Pawan Kumar Singh and Mark M. Jones and H Yan and Clint E. Carter},
  journal={Toxicology},
  year={1996},
  volume={107 1},
  pages={1-8}
}
In vivo CdCl2-induced apoptotic DNA fragmentation in the testes of the male Wistar rat has been demonstrated on agarose gel. Characteristic DNA migration patterns (laddering) provide evidence of apoptosis (programmed cell death) in testicular tissue of rats administered CdCl2 at a level of 0.03 mmol/kg 48 h previously. Evidence that administration of an appropriate cadmium chelating agent within the first 24 h can suppress some or all of the apoptotic changes in testicular DNA has also been… CONTINUE READING