In vivo studies of Scn5a+/− mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities

@inproceedings{Martin2010InVS,
  title={In vivo studies of Scn5a+/− mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities},
  author={Claire A Martin and Yanmin Zhang and Andrew A. Grace and Christopher L. -H. Huang},
  booktitle={Journal of electrocardiology},
  year={2010}
}
OBJECTIVES We investigate the extent to which the electrocardiographic (ECG) properties of intact Scn5a+/- mice reproduce the corresponding clinical Brugada syndrome phenotype and use this model to investigate the role of conduction and repolarization abnormalities in the arrhythmogenic mechanism. METHODS AND RESULTS The ECGs were obtained from anesthetized wild-type and Scn5a+/- mice, before and after administration of the known pro- and antiarrhythmic agents flecainide and quinidine. The… CONTINUE READING
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