In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans.

@article{Bscher2001InvivoSD,
  title={In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans.},
  author={Rainer B{\"u}scher and H Belger and Katrin Jennifer Eilmes and R Tellkamp and Joachim Radke and Stefan Dhein and Peter Friedrich Hoyer and Martin C Michel and Paul A. Insel and Otto Erich Brodde},
  journal={Pharmacogenetics},
  year={2001},
  volume={11 3},
  pages={199-205}
}
beta 1-adrenoceptors play a pivotal role in regulating contractility and heart rate in the human heart. Recently, a polymorphism of the beta 1-adrenoceptor has been detected: at amino acid position 389 either Gly or Arg has been found with the Gly389 exhibiting reduced responsiveness upon agonist-induced stimulation in vitro. In order to find out whether the Gly389 polymorphism exhibits blunted responsiveness also in vivo we studied, in healthy volunteers, the effects of exercise on heart rate… CONTINUE READING

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