In vivo stereospecific [3H]spiperone binding in rat brain: characteristics, regional distribution, kinetics and pharmacological properties.

@article{Barone1985InVS,
  title={In vivo stereospecific [3H]spiperone binding in rat brain: characteristics, regional distribution, kinetics and pharmacological properties.},
  author={Domenico Barone and Franco Luzzani and Alessandro Assandri and Giulio Galliani and Tiziana Mennini and Silvio Ken Garattini},
  journal={European journal of pharmacology},
  year={1985},
  volume={116 1-2},
  pages={
          63-74
        }
}
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Characterization of [3H]nemonapride binding to mouse brain dopamine D2 receptors assessedin vivo andex vivo for metabolic modeling in PET studies
TLDR
HPLC revealed that most of the radioactivity in the MB was [3H]NEM, whereas metabolites were found in the cytosol, and in the striatum, the SBex vivo increased with time, and was equivalent to the SBin vivo-2.
In vivo Binding of Spiperone and N-Methylspiperone to Dopaminergic and Serotonergic Sites in the Rat Brain: Multiple Modeling and Implications for PET Scanning
TLDR
The consequence of the present analysis for positron emission tomography is that the striatal/cerebellar activity ratio is not an accurate parameter of specific binding features at tracer doses of spiperone or N-methylspiperone.
In vivo labelling of rat brain dopamine D-2 receptors
TLDR
The present findings indicate that the in vivo binding of three radioactive ligands to a central dopamine D-2 receptor can be stereoselectively blocked by the enantiomers of raclopride and suggest that, under in vivo conditions, [3H]-raclopide and [3 H]-NPA may label a closely related receptor site.
In‐vivo Radiolabelled Oxiracetam Binding to Rat Brain
TLDR
Results suggest that in those cerebral structures oxiracetam binds to saturable sites, and there was a significant reduction of binding only in the septum, hippocampus and cerebral cortex after co‐injection with a 1000‐fold excess of unlabelled oxir acetam.
In vivo interaction of cabergoline with rat brain dopamine receptors labelled with [3H]N-n-propylnorapomorphine.
Synthesis and in vivo evaluation of [18F]-N-(p-nitrobenzyl)spiperone ([18F]PNBS) in rats.
From Fenfluramine Racemate to d‐Fenfluramine
TLDR
Evidence has been provided that d-fenfluramine preferentially uses 5-HT1 sites in the rat brain to cause anorexia in this animal species.
In vivo labeling of brain dopamine D2 receptors using the high-affinity specific D2 agonist [3H]CV 205–502
Definition of the In‐vivo Accumulation of [3H]spiperone in Brain using Haloperidol and Sulpiride to Determine Functional Dopamine Receptor Occupation
Abstract— The in‐vivo administration of [3H]spiperone caused an accumulation of radioactivity in the substantia nigra, tuberculum olfactorium, nucleus accumbens, striatum and frontal cortex when…
p-[18F]fluorobenzyltrozamicol ([18F]FBT): molecular decomposition- reconstitution approach to vesamicol receptor radioligands for positron emission tomography.
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References

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Regional in vivo binding of [3H]N-propylnorapomorphine in the mouse brain. Evidence for labelling of central dopamine receptors.
In vivo [3H]spiperone binding to the rat hippocampal formation: involvement of dopamine receptors.
Increased in vivo binding of 3H-pimozide in mouse striatum following repeated administration of haloperidol.
Quantitative assessment of heterogeneous 3H-spiperone binding to rat neostriatum and frontal cortex.
Characterization of specific in vivo binding of neuroleptic drugs in rat brain.
Spiperone: a ligand of choice for neuroleptic receptors. 2. Regional distribution and in vivo displacement of neuroleptic drugs.
In vivo binding of 3H-pimozide in mouse striatum: effects of dopamine agonists and antagonists.
Serotonergic component of neuroleptic receptors
TLDR
It is suggested that serotonergic, as well as dopamine agonists or antagonists for rat frontal cortex and striatal receptors are involved in the mechanism of action of neuroleptic drugs.
Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug.
TLDR
Since there was little desorption of [3H]apomorphine, the ligand permits extensive washing during routine assays for dopamine receptors, and facilitates biochemical purification of the receptor.
Specific Binding of [11C]Spiroperidol in Rat Brain In Vivo
TLDR
Spiroperidol labeled with carbon‐11, a shortlived positron‐emitting radionuclide, was used to determine the time course of specific binding of this radio‐ligand to the neuroleptic receptor in vivo in the rat, suggesting it may be useful for labeling Neuroleptic receptors in vivo for serial studies using positron emission transaxial tomography.
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