In vivo spin trapping of nitric oxide.

  title={In vivo spin trapping of nitric oxide.},
  author={Lawrence J. Berliner and Hirotada Fujii},
  journal={Antioxidants & redox signaling},
  volume={6 3},
The measurement of nitric oxide (NO) in biological samples has normally required destructive chemical techniques. The ability to detect NO non-invasively in living animals or excised organs has great potential using specialized electron paramagnetic resonance (EPR) methods. Although NO is paramagnetic, it cannot be observed directly unless it is complexed with ferrous iron-dithiocarbamate ligand spin trap complexes. Despite the minimally invasive nature of the technique, highly sensitive… CONTINUE READING

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