In-vivo single neuron axotomy triggers axon regeneration to restore synaptic density in specific cortical circuits.

@article{Canty2013InvivoSN,
  title={In-vivo single neuron axotomy triggers axon regeneration to restore synaptic density in specific cortical circuits.},
  author={Alison J. Canty and Lulu Huang and Johanna S. Jackson and G. E. Little and Graham Knott and Bohumil Maco and Vincenzo De Paola},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={2038}
}
To what extent, how and when axons respond to injury in the highly interconnected grey matter is poorly understood. Here we use two-photon imaging and focused ion beam-scanning electron microscopy to explore, at synaptic resolution, the regrowth capacity of several neuronal populations in the intact brain. Time-lapse analysis of >100 individually ablated axons for periods of up to a year reveals a surprising inability to regenerate even in a glial scar-free environment. However, depending on… CONTINUE READING
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