In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex.

@article{Mascaro2013InVS,
  title={In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex.},
  author={Anna Letizia Allegra Mascaro and Paolo Cesare and Leonardo Sacconi and Giorgio Grasselli and Georgia Mandolesi and Bohumil Maco and Graham Knott and Lieven Huang and Vincenzo De Paola and Piergiorgio Strata and Francesco Pavone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 26},
  pages={10824-9}
}
Plasticity in the central nervous system in response to injury is a complex process involving axonal remodeling regulated by specific molecular pathways. Here, we dissected the role of growth-associated protein 43 (GAP-43; also known as neuromodulin and B-50) in axonal structural plasticity by using, as a model, climbing fibers. Single axonal branches were dissected by laser axotomy, avoiding collateral damage to the adjacent dendrite and the formation of a persistent glial scar. Despite the… CONTINUE READING