In vivo self-interaction of nodavirus RNA replicase protein a revealed by fluorescence resonance energy transfer.

@article{Dye2005InVS,
  title={In vivo self-interaction of nodavirus RNA replicase protein a revealed by fluorescence resonance energy transfer.},
  author={Billy T. Dye and D J Miller and Paul Ahlquist},
  journal={Journal of virology},
  year={2005},
  volume={79 14},
  pages={8909-19}
}
Flock house virus (FHV) is the best-characterized member of the Nodaviridae, a family of small, positive-strand RNA viruses. Unlike most RNA viruses, FHV encodes only a single polypeptide, protein A, that is required for RNA replication. Protein A contains a C-proximal RNA-dependent RNA polymerase domain and localizes via an N-terminal transmembrane domain to the outer mitochondrial membrane, where FHV RNA replication takes place in association with invaginations referred to as spherules. We… CONTINUE READING
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