In vivo selection using a cell-growth switch

  title={In vivo selection using a cell-growth switch},
  author={Liqing Jin and Hui Zeng and Sylvia Chien and Kevin G. Otto and Robert E. Richard and David W. Emery and C. Anthony Blau},
  journal={Nature Genetics},
A major obstacle to stem-cell gene therapy rests in the inability to deliver a gene into a therapeutically relevant fraction of stem cells. One way to circumvent this obstacle is to use selection. Vectors containing two linked genes serve as the basis for selection, with one gene encoding a selectable product and the other, a therapeutic protein. Applying selection in vivo has the potential to bring a minor population of genetically corrected cells into the therapeutic range. But strategies for… CONTINUE READING

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