In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum-cephalosporins.

@article{MartnezMartnez1996InVS,
  title={In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum-cephalosporins.},
  author={Luis Horacio Mart{\'i}nez-Mart{\'i}nez and Santiago Hern{\'a}ndez-All{\'e}s and Sebastian Fernandez Alberti and Juan Miguel Tom{\'a}s and Vicente Javier Bened{\'i} and George A. Jacoby},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 2},
  pages={342-8}
}
Four Klebsiella pneumoniae isolates (LB1, LB2, LB3, and LB4) with increased antimicrobial resistance were obtained from the same patient. The four isolates were indistinguishable in biotype, plasmid content, lipopolysaccharide, and DNA analysis by pulse-field gel electrophoresis. Isolate LB1 made TEM-1 and SHV-1 beta-lactamases. Isolates LB2, LB3, and LB4 produced SHV-5 in addition to TEM-1 and SHV-1. MICs of cefoxitin, ceftazidime, and cefotaxime against LB1 were 4, 1, and 0.06 micrograms/ml… CONTINUE READING
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