In vivo roles of donor and host dendritic cells in allogeneic immune response: cluster formation with host proliferating T cells.

@article{Saiki2001InVR,
  title={In vivo roles of donor and host dendritic cells in allogeneic immune response: cluster formation with host proliferating T cells.},
  author={Toyonori Saiki and Taichi Ezaki and Michio Ogawa and Kunihiko Maeda and H. Yagita and Kenjiro Matsuno},
  journal={Journal of leukocyte biology},
  year={2001},
  volume={69 5},
  pages={705-12}
}
Possible roles of dendritic cells (DCs) in allogeneic immune responses in host lymphoid tissues were characterized in situ by using rat DC transfer and cardiac transplantation models. When allogeneic DCs were intravenously injected, these cells selectively migrated to the T-cell area of hepatic lymph nodes, with peak accumulation at 18 h after injection. Donor DCs and proliferating host T cells formed clusters (rosettes) in which the T-cell proliferative response started. The donor DCs were… CONTINUE READING

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