In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules

@article{Yan2006InVR,
  title={In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules},
  author={Jingbo Yan and Vrajesh V. Parekh and Yanice V M{\'e}ndez-Fern{\'a}ndez and Danyvid Olivares-Villag{\'o}mez and Srdjan M Dragovic and T. Hill and Derry Charles Roopenian and Sebastian Joyce and Luc Van Kaer},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={647 - 659}
}
Endoplasmic reticulum (ER)-associated aminopeptidase (ERAP)1 has been implicated in the final proteolytic processing of peptides presented by major histocompatibility complex (MHC) class I molecules. To evaluate the in vivo role of ERAP1, we have generated ERAP1-deficient mice. Cell surface expression of the class Ia molecules H-2Kb and H-2Db and of the class Ib molecule Qa-2 was significantly reduced in these animals. Although cells from mutant animals exhibited reduced capacity to present… CONTINUE READING