In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders

@article{Meyer2009InvivoRM,
  title={In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders},
  author={Urs Meyer and Joram Feldon and S Hossein Fatemi},
  journal={Neuroscience & Biobehavioral Reviews},
  year={2009},
  volume={33},
  pages={1061-1079}
}
Based on the epidemiological association between maternal infection during pregnancy and enhanced risk of neurodevelopmental brain disorders in the offspring, a number of in-vivo models have been established in rats and mice in order to study this link on an experimental basis. These models provide indispensable experimental tools to test the hypothesis of causality in human epidemiological associations, and to explore the critical neuroimmunological and developmental factors involved in… CONTINUE READING

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