In vivo rodent micronucleus assay: protocol, conduct and data interpretation.

  title={In vivo rodent micronucleus assay: protocol, conduct and data interpretation.},
  author={G. Gandhi Krishna and Makoto Hayashi},
  journal={Mutation research},
  volume={455 1-2},
In vivo rodent micronucleus assay has been widely used to detect genotoxicity. Evaluation of micronucleus induction is the primary in vivo test in a battery of genotoxicity tests and is recommended by the regulatory agencies around the globe to be conducted as part of product safety assessment. The assay, when performed appropriately, detects both clastogenicity and aneugenicity. Methods for performing micronucleus evaluation have evolved since its initial description in the 1970s. In recent… CONTINUE READING
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