In vivo retinal imaging by optical coherence tomography.
@article{Swanson1993InVR, title={In vivo retinal imaging by optical coherence tomography.}, author={Eric A. Swanson and Joseph A. Izatt and Michael Richard Hee and David Huang and C. P. Lin and Joel S. Schuman and Carmen A. Puliafito and James G. Fujimoto}, journal={Optics letters}, year={1993}, volume={18 21}, pages={ 1864-6 } }
We describe what are to our knowledge the first in vivo measurements of human retinal structure with optical coherence tomography. These images represent the highest depth resolution in vivo retinal images to date. The tomographic system, image-processing techniques, and examples of high-resolution tomographs and their clinical relevance are discussed.
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References
SHOWING 1-10 OF 12 REFERENCES
Optical Coherence Tomography
- PhysicsLEOS '92 Conference Proceedings
- 1992
Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.
Micron‐resolution ranging of cornea anterior chamber by optical reflectometry
- MedicineLasers in surgery and medicine
- 1991
Noncontact, high resolution measurements of anterior eye structures using optical coherence domain reflectometry are described, and sensitivities to reflected signals as small as 10−10 of the incident power are achieved by heterodyne detection.
Optical coherence-domain reflectometry: a new optical evaluation technique.
- PhysicsOptics letters
- 1987
An optical evaluation technique is described that is suitable for determining the positions and magnitudes of reflection sites within miniature optical assemblies. This method utilizes the coherence…
Quantitative studies of retinal nerve fiber layer defects.
- Medicine, BiologyArchives of ophthalmology
- 1982
In 12 eyes with NFL lesions induced by orbital optic nerve trauma, clinical detection of NFL atrophy was possible after loss of 50% of the neural tissue in a given area.
Confocal scanning laser ophthalmoscope.
- Medicine, PhysicsApplied optics
- 1987
A confocal scanning imager moves an illumination spot over the object and a (virtual) detector synchronously over the image, and chooses selectively among direct and scattered components of the light returning from the eye.
Eye-length measurement by interferometry with partially coherent light.
- PhysicsOptics letters
- 1988
A first series of in vivo measurements acoustically determined eye length, with a multimode semiconductor laser, within a precision of 0.03 mm.
Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging
- Physics
- 1992
We present a polarization-sensitive optical coherence-domain reflectometer capable of characterizing the phase retardation between orthogonal linear polarization modes at each reflection point in a…
Submillimeter optical reflectometry
- Physics
- 1989
The development of optical reflectometers with a spatial resolution in the submillimeter range is reviewed. Optical time-domain reflectometers (OTDRs) and optical low-coherence reflectometers (OLCRs)…
High-resolution reflectometry in biological tissues.
- PhysicsOptics letters
- 1992
Optical low-coherence ref lectometry is applied for the first time to the authors' knowledge to investigate diffusive biological tissues with a single-mode fiber probe, and this noninvasive method allows one to determine optical parameters, such as the index of refraction and the transmission properties, and the tissue thickness.
High-speed optical coherence domain reflectometry.
- PhysicsOptics letters
- 1992
Two applications are presented: the noninvasive measurement of anterior eye structure in a rabbit inυiυo and the characterization of reflections and interelement spacing in a multielement lens.