In vivo response to high-resolution variation of Tbx1 mRNA dosage.

@article{Zhang2007InVR,
  title={In vivo response to high-resolution variation of Tbx1 mRNA dosage.},
  author={Zhen Zhang and Antonio Baldini},
  journal={Human molecular genetics},
  year={2007},
  volume={17 1},
  pages={
          150-7
        }
}
  • Zhen Zhang, Antonio Baldini
  • Published in Human molecular genetics 2007
  • Biology, Medicine
  • Mouse modeling of haploinsufficiency syndromes and, in general, of syndromes caused by gene dosage imbalance, is often unsatisfactory because loss (or gain) of one copy of the gene of interest is insufficient to recapitulate the disease phenotype. In this study, we use Tbx1 mutants, which model one of the most common haploinsufficiency disorders, the 22q11.2DS/DiGeorge/Velocardiofacial syndrome, to test the feasibility of high resolution dosage manipulation to generate mouse models that more… CONTINUE READING

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