In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus.

@article{Yoder1997InVR,
  title={In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus.},
  author={Mervin C. Yoder and Kelly K Hiatt and Priyabrata Mukherjee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 13},
  pages={6776-80}
}
The murine yolk sac, being the first site of embryonic blood cell production, has long been theorized to contain the migrating hematopoietic stem cells (HSC) that seed the liver and initiate hematopoiesis on day 10.0 postcoitus (pc). However, it remains controversial whether yolk sac cells isolated before day 11.0 pc possess any long-term repopulating HSC activity upon transplantation into adult recipient mice. We hypothesized that failure to demonstrate engraftment of day <11.0 yolk sac cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 107 extracted citations

References

Publications referenced by this paper.
Showing 1-3 of 3 references

Yoder et al

T. Leemhuis, M. C. Yoder, +5 authors 1215–1224. 6780 Developmental Biology
Proc. Natl. Acad. Sci. USA 94 • 1997
View 1 Excerpt

The Mouse (Oxford

R. Rugh
1993
View 1 Excerpt

Cold Spring Harbor Symp

B. Clarkson, P. A. Marks, +5 authors W. Raschke
Quant . Biol . • 1977

Similar Papers

Loading similar papers…