In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus.

@article{Yoder1997InVR,
  title={In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus.},
  author={M. Yoder and K. Hiatt and Priyabrata Mukherjee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 13},
  pages={
          6776-80
        }
}
  • M. Yoder, K. Hiatt, Priyabrata Mukherjee
  • Published 1997
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • The murine yolk sac, being the first site of embryonic blood cell production, has long been theorized to contain the migrating hematopoietic stem cells (HSC) that seed the liver and initiate hematopoiesis on day 10.0 postcoitus (pc). However, it remains controversial whether yolk sac cells isolated before day 11.0 pc possess any long-term repopulating HSC activity upon transplantation into adult recipient mice. We hypothesized that failure to demonstrate engraftment of day <11.0 yolk sac cells… CONTINUE READING
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    References

    SHOWING 1-10 OF 31 REFERENCES
    Hemopoietic stem cells in murine embryonic yolk sac and peripheral blood.
    • 108
    • PDF
    Hematopoietic stem cell emergence in embryonic life: developmental hematology revisited.
    • B. Péault
    • Biology, Medicine
    • Journal of hematotherapy
    • 1996
    • 63
    In vitro induction of adult erythropoiesis in early mouse yolk sac.
    • 52
    • PDF