In vivo remote delivery of DNA encoding for hypoxia-inducible factor 1 alpha reduces myocardial infarct size.

@article{Czibik2009InVR,
  title={In vivo remote delivery of DNA encoding for hypoxia-inducible factor 1 alpha reduces myocardial infarct size.},
  author={Gabor Czibik and Vladimir N. Martinov and Arno Ruusalepp and Julia Sagave and {\O}ivind Skare and Guro Valen},
  journal={Clinical and translational science},
  year={2009},
  volume={2 1},
  pages={
          33-40
        }
}
We tested if remote gene delivery of hypoxia-inducible factor 1 alpha (HIF-1 alpha) protected hearts against induced ischemia, hypothesizing that gene delivery into skeletal muscle may lead to secretion of proteins with actions elsewhere. Murine quadriceps muscles were transfected with DNA encoding for human HIF-1 alpha, which resulted in a local, but lasting expression (mRNA and protein, where the latter had nuclear localization). Subjection of isolated hearts to global ischemia and… CONTINUE READING
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