In vivo remodeling and structural characterization of fibrin-based tissue-engineered heart valves in the adult sheep model.

@article{Flanagan2009InVR,
  title={In vivo remodeling and structural characterization of fibrin-based tissue-engineered heart valves in the adult sheep model.},
  author={Thomas Cormac Flanagan and J{\"o}rg Siegmar Sachweh and Julia Frese and Heike Schnoering and Nina Gronloh and Sabine Koch and Ren{\'e} Hany Tolba and Thomas Schmitz-Rode and Stefan Jockenhoevel},
  journal={Tissue engineering. Part A},
  year={2009},
  volume={15 10},
  pages={2965-76}
}
Autologous fibrin-based tissue-engineered heart valves have demonstrated excellent potential as patient-derived valve replacements. The present pilot study aims to evaluate the structure and mechanical durability of fibrin-based heart valves after implantation in a large-animal model (sheep). Tissue-engineered heart valves were molded using a fibrin scaffold and autologous arterial-derived cells before 28 days of mechanical conditioning. Conditioned valves were subsequently implanted in the… CONTINUE READING
52 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…