In vivo relevance of polymorphic Interleukin 8 promoter haplotype for the systemic immune response to LPS in Holstein-Friesian calves.

Abstract

Interleukin 8, also known as CXC chemokine ligand 8 (CXCL8), is a critical chemokine in the recruitment of leukocytes to sites of infection and is a potent mediator of inflammation. We previously discovered 29 polymorphic sites in the promoter region of the bovine Interleukin 8 gene, which segregate into two distinct haplotypes, denoted IL8-h1 and IL8-h2… (More)
DOI: 10.1016/j.vetimm.2016.09.006

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