In vivo regulation of growth hormone-stimulated gene transcription by STAT5b.

@article{Woelfle2004InVR,
  title={In vivo regulation of growth hormone-stimulated gene transcription by STAT5b.},
  author={Joachim Woelfle and Peter Rotwein},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={286 3},
  pages={
          E393-401
        }
}
The long-term effects of growth hormone (GH) are mediated through coordinated changes in gene expression that are the outcome of interactions between hormone-activated signal transduction pathways and specific feedback loops. Recent studies in mice have implicated the transcription factor STAT5b as part of the GH-regulated somatic growth pathway, because mice lacking this protein showed diminished growth rates. To assess the role of Stat5b in GH-stimulated gene expression, we have delivered… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

SOCS: physiological suppressors of cytokine signaling.

  • Journal of cell science
  • 2000
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Signaling pathways activated by the growth hormone receptor

  • Trends in Endocrinology & Metabolism
  • 2001
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Circulating levels of IGF-1 directly regulate bone growth and density.

  • The Journal of clinical investigation
  • 2002
VIEW 2 EXCERPTS