In vivo regulation of B lymphocyte production in the bone marrow: effects and mechanism of action of exogenous stimuli on pre-B cell proliferation and lymphocyte turnover.

Abstract

The present studies demonstrate that a single administration of an extrinsic agent (SRBC) can stimulate increased production of B lymphocytes in mouse bone marrow as revealed by 2 in vivo assays which quantitate pre-B cell proliferation and small lymphocyte renewal, respectively. The mechanisms mediating this stimulatory effect are sensitive to silica in… (More)

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