In vivo recruitment of hematopoietic cells using stromal cell-derived factor 1 alpha-loaded heparinized three-dimensional collagen scaffolds.

@article{Bladergroen2009InVR,
  title={In vivo recruitment of hematopoietic cells using stromal cell-derived factor 1 alpha-loaded heparinized three-dimensional collagen scaffolds.},
  author={Bellinda A. Bladergroen and Bas Siebum and Kim G C Siebers-Vermeulen and Toin H van Kuppevelt and Andr{\'e} A. Poot and Jan Feijen and Carl G. Figdor and Ruurd Torensma},
  journal={Tissue engineering. Part A},
  year={2009},
  volume={15 7},
  pages={1591-9}
}
Implantable three-dimensional (3D) constructs to engineer tissue have great therapeutic potential in regenerative medicine and immunotherapy. However, autonomous recruitment of cells into the engineered scaffold in vivo is hampered by lack of attracting scaffolds. As a first step to engineering immune tissue, 3D collagen scaffolds were investigated for their ability to enhance in vivo recruitment and growth of various hematopoietic cells. Scaffolds containing immobilized heparin to trap the… CONTINUE READING

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